- a) The direct fluorescent antibody test is the gold standard for rabies diagnosis. The test should be performed in accordance with the established national standardized protocol (www.cdc.gov/rabies/pdf/rabiesdfaspv2.pdf) by a qualified laboratory that has been designated by the local or state health department. 20,21 Animals submitted for rabies testing should be euthanized 22,23 in such a way as to maintain the integrity of the brain so that the laboratory can recognize anatomic structures. Except in the case of very small animals, such as bats, only the head or entire brain (including brainstem) should be submitted to the laboratory. To facilitate prompt laboratory testing, submitted specimens should be stored and shipped under refrigeration without delay. The need to thaw frozen specimens will delay testing. Chemical fixation of tissues should be avoided to prevent significant testing delays and because such fixation might preclude reliable testing. Questions about testing of fixed tissues should be directed to the local rabies laboratory or public health department.
- b) Rabies testing should be available outside of normal business hours at the discretion of public health officials to expedite exposure management decisions. 20 When confirmatory testing is needed by state health departments (eg, in the event of inconclusive results, unusual species, or mass exposures), the CDC rabies laboratory can provide additional testing and results within 24 hours of sample receipt. 24
- c) Professional associations such as the Association of Public Health Laboratories should advocate for, distribute, and promote the development of guidelines for routinely assessing testing practices within rabies laboratories to ensure maintenance of quality and safety.
- d) A direct rapid immunohistochemical test (referred to as dRIT) is being used by trained field personnel in surveillance programs for specimens not involved in human or domestic animal exposures. 25–28 All positive direct rapid immunohistochemical test results need to be confirmed by means of direct fluorescent antibody testing at a qualified laboratory.
- e) Currently, there are no commercially available, USDA-licensed rapid test kits for rabies diagnosis. Unlicensed tests should not be used owing to the following concerns: sensitivity and specificity of these tests are not known, the tests have not been validated against current standard methods, the excretion of virus in the saliva is intermittent and the amount varies over time, any unlicensed test result would need to be confirmed by validated methods such as direct fluorescent antibody testing on brain tissue, and the interpretation of results from unlicensed tests may place exposed animals and persons at risk.
B. Prevention and control methods in domestic and confined animals
- 1. Preexposure vaccination and management. Adherence to a regular rabies vaccination schedule is critical to protect animals against recognized and unrecognized rabies exposures. Parenteral animal rabies vaccines should be administered only by or under the direct supervision of a licensed veterinarian on premises. Rabies vaccines may be administered under the supervision of a licensed veterinarian to animals held in animal shelters before release. 33,34 The veterinarian signing a rabies vaccination certificate must ensure that the person who administered the vaccine is identified on the certificate and has been appropriately trained in vaccine storage, handling, and administration and in the management of adverse events. This ensures that a qualified and responsible person can be held accountable for properly vaccinating the animal. Within 28 days after initial vaccination, a peak rabies virus antibody titer is expected, and the animal can be considered immunized. 31,35–37 Regardless of the age of the animal at initial vaccination, a booster vaccination should be administered 1 year later (see Part II and Appendix 1). An animal is currently vaccinated and is considered immunized immediately after any booster vaccination. 38,39
- a) Booster vaccination. Following the initial vaccination, booster vaccinations should be given in a manner consistent with the manufacturer's label. If a previously vaccinated animal is overdue for any booster vaccination, including the first booster vaccination due 1 year after initial vaccination, it should be given a booster vaccination. Immediately after this booster vaccination, the animal is considered currently vaccinated and should be placed on a booster vaccination schedule consistent with the label of the vaccine used. There are no laboratory or epidemiological data to support the annual or biennial administration of 3-year vaccines after completion of the initial vaccine series (ie, the initial vaccination and 1-year booster vaccination).
- b) Dogs, cats, and ferrets. All dogs, cats, and ferrets should be vaccinated against rabies and revaccinated in accordance with recommendations in this compendium (Appendix 1).
- c) Livestock. All horses should be vaccinated against rabies. 40 Livestock, including species for which licensed vaccines are not available, that have frequent contact with humans (eg, in petting zoos, fairs, and other public exhibitions) should be vaccinated against rabies. 41,42 Consideration should also be given to vaccinating livestock that are particularly valuable.
- d) Captive wild animals and wild animal hybrids (the offspring of wild animals crossbred to domestic animals).
- (1) Wild animals and wild animal hybrids should not be kept as pets. 43,44 No parenteral rabies vaccines are licensed for use in wild animals or wild animal hybrids. 45
- (2) Animals that are farmed (eg, for food, fur, or fiber) or maintained in exhibits or zoological parks and that are not completely excluded from all contact with rabies vectors can become infected. 46 Moreover, wild animals might be incubating rabies when initially captured. Therefore, wild-caught animals susceptible to rabies should be quarantined for a minimum of 6 months.
- (3) Employees who work with animals in exhibits or zoological parks should receive preexposure rabies vaccination. The use of preexposure or postexposure rabies vaccination for handlers who work with animals at such facilities might reduce the need for euthanasia of captive animals that expose handlers. Carnivores and bats should be housed in a manner that precludes direct contact with the public. 41,42 Consideration may be given to vaccinating animals that are particularly valuable (see Part II. D. Vaccination of wildlife and wild animal hybrids).
- a) Areas with dog-to-dog rabies transmission. Canine rabies virus variants have been eliminated from the United States 3,7 ; however, rabid dogs and a rabid cat have been introduced into the continental United States from areas with dog-to-dog rabies transmission. 4–6,48,49 The movement of dogs for the purposes of adoption or sale from areas with dog-to-dog rabies transmission increases the risk of introducing canine-transmitted rabies to areas where it does not currently exist, and this practice should be prohibited.
- b) International importation. Current federal regulations are insufficient to prevent the introduction of rabid animals into the United States and must be strengthened and appropriately enforced. 4–6,48,49 The CDC and USDA APHIS have regulatory authority over the importation of dogs and cats into the United States. 6 Importers of dogs must comply with rabies vaccination requirements. 50,51 These regulations require that dogs from rabies-endemic countries be currently vaccinated against rabies prior to importation. The appropriate health official of the state of destination should be notified by the appropriate federal authorities within 72 hours of the arrival of any unvaccinated imported dog required to be placed in confinement (as defined by the CDC 52 ) under these regulations. Failure of the owner to comply with these confinement requirements should be promptly reported to the CDC's Division of Global Migration and Quarantine (CDCAnimalImports@cdc.gov). All imported dogs and cats are also subject to state and local laws governing rabies and should be currently vaccinated against rabies with USDA-licensed products in accordance with this compendium. Failure of the owner to comply with state or local requirements should be referred to the appropriate state or local official.
- c) Interstate movement (including commonwealths and territories). Before interstate movement occurs, dogs, cats, ferrets, and horses should be currently vaccinated against rabies in accordance with this compendium. Animals in transit should be accompanied by a current, valid rabies vaccination certificate such as Form 51 from the National Association of State Public Health Veterinarians. 53 When an interstate health certificate or certificate of veterinary inspection is required, it should contain the same rabies vaccination information as Form 51.
- a) Identification. Dogs, cats, and ferrets should be identified (eg, metal or plastic tags or microchips) to allow for verification of rabies vaccination status.
- b) Licensure. Registration or licensure of all dogs, cats, and ferrets is an integral component of an effective rabies control program. A fee is frequently charged for such licensure, and revenues collected are used to maintain rabies or animal control activities. Evidence of current vaccination should be an essential prerequisite to licensure.
- c) Canvassing. House-to-house canvassing by animal control officials facilitates enforcement of vaccination and licensure requirements.
- d) Citations. Citations are legal summonses issued to owners for violations, including the failure to vaccinate or license their animals. The authority for officers to issue citations should be an integral part of animal control programs.
- e) Animal control. All local jurisdictions should incorporate training and continuing education of personnel regarding stray-animal control, leash laws, animal bite prevention, and rabies prevention and control into their programs.
- f) Public education. All local jurisdictions should incorporate education covering responsible pet ownership, bite prevention, and appropriate veterinary care into their programs.
- a) Dogs, cats, and ferrets. Any illness in an exposed animal should be reported immediately to the local health department. If signs suggestive of rabies develop (eg, paralysis or seizures), the animal should be euthanized, and the head or entire brain (including brainstem) should be submitted for testing (see Part I.A. 10. Rabies diagnosis).
- (1) Dogs, cats, and ferrets that are current on rabies vaccination should immediately receive veterinary medical care for assessment, wound cleansing, and booster vaccination. The animal should be kept under the owner's control and observed for 45 days.
- (2) Dogs, cats, and ferrets that have never been vaccinated should be euthanized immediately. There are currently no USDA-licensed biologics for postexposure prophylaxis of previously unvaccinated domestic animals, and there is evidence that the use of vaccine alone will not reliably prevent the disease in these animals. 58 If the owner is unwilling to have the animal euthanized, the animal should be placed in strict quarantine for 4 (dogs and cats) or 6 (ferrets) months. Strict quarantine in this context refers to confinement in an enclosure that precludes direct contact with people and other animals. A rabies vaccine should be administered at the time of entry into quarantine to bring the animal up to current rabies vaccination status. Administration of vaccine should be done as soon as possible. It is recommended that the period from exposure to vaccination not exceed 96 hours. 59,60 If vaccination is delayed, public health officials may consider increasing the quarantine period for dogs and cats from 4 to 6 months, taking into consideration factors such as the severity of exposure, the length of delay in vaccination, current health status, and local rabies epidemiology.
- (3) Dogs and cats that are overdue for a booster vaccination and that have appropriate documentation of having received a USDA-licensed rabies vaccine at least once previously should immediately receive veterinary medical care for assessment, wound cleansing, and booster vaccination. The animal should be kept under the owner's control and observed for 45 days. 39 If booster vaccination is delayed, public health officials may consider increasing the observation period for the animal, taking into consideration factors such as the severity of exposure, the length of delay in booster vaccination, current health status, and local rabies epidemiology.
- (4) Dogs and cats that are overdue for a booster vaccination and without appropriate documentation of having received a USDA-licensed rabies vaccine at least once previously should immediately receive veterinary medical care for assessment, wound cleansing, and consultation with local public health authorities.
- (a) The animal can be treated as unvaccinated, immediately given a booster vaccination, and placed in strict quarantine (see Part I. B. 5. a) (2)).
- (b) Alternatively, prior to booster vaccination, the attending veterinarian may request guidance from the local public health authorities in the possible use of prospective serologic monitoring. Such monitoring would entail collecting paired blood samples to document prior vaccination by providing evidence of an anamnestic response to booster vaccination. If an adequate anamnestic response is documented, the animal can be considered to be overdue for booster vaccination (see Part I. B. 5. a) (3)) and observed for 45 days. 39 If there is inadequate evidence of an anamnestic response, the animal is considered to have never been vaccinated and should be placed in strict quarantine (see Part I. B. 5. a) (2)).
- (1) Livestock that have never been vaccinated should be euthanized immediately. Animals that are not euthanized should be confined and observed on a case-by-case basis for 6 months.
- (2) Livestock that are current on rabies vaccination with a USDA-licensed vaccine approved for that species should be given a booster vaccination immediately and observed for 45 days.
- (3) Livestock overdue for a booster vaccination should be evaluated on a case-by-case basis, taking into consideration factors such as severity of exposure, time elapsed since last vaccination, number of previous vaccinations, current health status, and local rabies epidemiology, to determine need for euthanasia or immediate booster vaccination followed by observation or strict quarantine.
- (4) Multiple rabid animals in a herd and herbivore-to-herbivore transmission of rabies are uncommon. 61 Therefore, restricting the rest of the herd if a single animal has been exposed to or infected with rabies is usually not necessary.
- (5) Rabies virus is widely distributed in the tissues of rabid animals. 62–64 Tissues and products from a rabid animal should not be used for human or animal consumption 65,66 or transplantation. 67 However, pasteurization and cooking will inactivate rabies virus. 68 Therefore, inadvertently drinking pasteurized milk or eating thoroughly cooked animal products does not constitute a rabies exposure.
- (6) Handling and consumption of uncooked tissues from exposed animals might carry a risk for rabies transmission. 69 Persons handling exposed animals, carcasses, and tissues should use appropriate barrier precautions. 69,70 State and local public health authorities, state meat inspectors, and the USDA Food Safety and Inspection Service should be notified if exposures occur in animals intended for commercial use. Animals should not be presented for slaughter in a USDA-regulated establishment if such animals originate from a quarantine area and have not been approved for release by the proper authority. If an exposed animal is to be custom slaughtered or home slaughtered for consumption, it should be slaughtered immediately after exposure, and all tissues should be cooked thoroughly.
- a) Dogs, cats, and ferrets. Rabies virus is excreted in the saliva of infected dogs, cats, and ferrets during illness and for only a few days before the onset of clinical signs or death. 71–73 Regardless of rabies vaccination status, a healthy dog, cat, or ferret that exposes a person should be confined and observed daily for 10 days from the time of the exposure 74 ; administration of rabies vaccine to the animal is not recommended during the observation period to avoid confusing signs of rabies with rare adverse vaccine reactions. 15 Any illness in the animal should be reported immediately to the local health department. Such animals should be evaluated by a veterinarian at the first sign of illness during confinement. If signs suggestive of rabies develop, the animal should be euthanized, and the head or entire brain (including brainstem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis). Any stray or unwanted dog, cat, or ferret that exposes a person may be euthanized immediately, and the head or entire brain (including brainstem) should be submitted for testing (see Part I. A. 10. Rabies diagnosis).
- b) Other animals. Other animals that might have exposed a person to rabies should be reported immediately to the local health department. Management of animals other than dogs, cats, and ferrets depends on the species, the circumstances of the exposure, the epidemiology of rabies in the area, the exposing animal's history and current health status, and the animal's potential for exposure to rabies. The shedding period for rabies virus is undetermined for most species. Previous vaccination of these animals might not preclude the necessity for euthanasia and testing.
- • Characterize the virus at the national reference laboratory.
- • Identify and control the source of the introduction.
- • Enhance laboratory-based surveillance in wild and domestic animals.
- • Increase animal rabies vaccination rates.
- • Restrict the movement of animals.
- • Evaluate the need for wildlife intervention activities (eg, point infection control, trapvaccinate-release programs, and oral rabies vaccination programs).
- • Provide public and professional outreach and education.
- • Coordinate relief efforts of individuals and organizations with the local emergency operations center before deployment.
- • Examine each animal at a triage site for possible bite injuries or signs of rabies.
- • Isolate animals exhibiting signs of rabies pending evaluation by a veterinarian.
- • Ensure that all animals have a unique identifier.
- • Administer a rabies vaccine to all dogs, cats, and ferrets unless reliable proof of current vaccination exists.
- • Adopt minimum standards for animal caretakers as feasible, including use of personal protective equipment, completion of the preexposure rabies vaccination series prior to deployment, and provision of appropriate training. 87
- • Maintain documentation of animal disposition and location (eg, returned to owner, died or euthanized, adopted, or relocated to another shelter with address of new location).
- • Provide facilities to confine and observe animals involved in exposures (see Part I. B. 6. Management of animals that bite humans).
- • Report human exposures to appropriate public health authorities (see Part I. A. 2. Rabies virus exposure).
C. Prevention and control methods related to wildlife
The public should be warned not to handle or feed wild mammals. Wild mammals and wild animal hybrids that expose persons, pets, or livestock should be considered for euthanasia and rabies testing. A person exposed by any wild mammal should immediately wash the wound thoroughly and report the incident to a health-care provider who, in consultation with public health authorities, can evaluate the need for postexposure prophylaxis. 11,12
Translocating infected wildlife has contributed to the spread of rabies, 75–80,88 and animals that appear healthy can still be rabid. Therefore, translocation (ie, moving live animals from their point of capture and releasing them) of known rabies reservoir species should be prohibited. 89 Whereas state-regulated wildlife rehabilitators and nuisance-wildlife control operators should play a role in a comprehensive rabies control program, minimum standards for these persons who handle wild mammals should include rabies preexposure vaccination, specific rabies prevention and control training, and ongoing continuing education.
- 1. Carnivores. The use of oral rabies vaccines for mass vaccination of free-ranging wildlife should be considered in selected situations, with the approval of appropriate state and local agencies. 16,90 There have been documented successes using oral rabies vaccines to control rabies in wildlife in North America. 90–93 The currently licensed vaccinia-vectored oral rabies vaccine is labeled for use in raccoons and coyotes. Research to improve existing oral rabies vaccine and baits and to develop and test novel products to determine safety and efficacy must be encouraged. The distribution of oral rabies vaccines should be based on scientific assessments of the target species and followed by timely and appropriate analysis of surveillance data, with results provided to all stakeholders. In addition, parenteral vaccination (trap-vaccinate-release) of wildlife rabies reservoir species may be integrated into coordinated oral rabies vaccine programs to enhance their effectiveness. Continuous and persistent programs for trapping or poisoning wildlife are not effective in reducing populations of wildlife rabies reservoir species on a statewide basis. However, limited population control in high-contact areas (eg, picnic grounds, camps, and suburban areas) might be indicated for the removal of selected high-risk species of wildlife. State agriculture, public health, and wildlife agencies should be consulted for planning, coordination, and evaluation of vaccination or point infection control programs. 16
- 2. Bats. From the 1950s to today, indigenous rabid bats have been reported from every state except Hawaii and have caused rabies in at least 54 humans in the United States. 94–103 Bats should be excluded, using appropriate methods, from houses, public buildings, and adjacent structures to prevent direct association with humans. 104,105 Such structures should then be made bat-proof by sealing entrances used by bats. Controlling rabies in bats through programs designed to reduce bat populations is neither feasible nor desirable.
Part II. Recommendations for Parenteral Rabies Vaccination Procedures
A. Vaccine administration
All animal rabies vaccines should be restricted to use by or under the direct supervision of a veterinarian, 106 except as recommended otherwise (see Part I. B. 1. Preexposure vaccination and management).
B. Vaccine selection
All vaccines licensed by the USDA and marketed in the United States at the time of publication of this compendium are listed (Appendix 1). Newly approved vaccines and changes in label specifications made subsequent to publication should be considered as part of this list. Any of the listed vaccines can be used for revaccination, even if the product is not the same as the one previously administered. Vaccines used in state and local rabies control programs should have at least a 3-year duration of immunity. This constitutes the most effective method of increasing the proportion of immunized dogs and cats in any population. 107
C. Adverse events
Currently, no epidemiological association exists between any particular licensed vaccine product and adverse events. 15,34,108–110 Although rare, adverse events such as vomiting, injection site swelling, lethargy, hypersensitivity, and the occurrence of rabies despite previous vaccination of an animal have been reported. Adverse events should be reported to the vaccine manufacturer and to USDA APHIS's Center for Veterinary Biologics (www.aphis.usda.gov; search for “adverse event reporting”). Although ill animals may not have a full immunologic response to vaccination, there is no evidence to suggest that adverse events are more likely to occur with rabies vaccination of ill than healthy animals. A veterinarian choosing to temporarily delay vaccinating an animal with an acute illness or condition should ensure that the animal is vaccinated as soon as possible. Animals with a previous history of anaphylaxis can be medically managed and observed after vaccination. 56 Severe adverse events related to rabies vaccination are extremely rare in animals. Decisions concerning rabies vaccination of animals with well-documented severe adverse events to rabies vaccine must be made within the context of a valid veterinarian-client-patient relationship. Due consideration should be given to the attendant risks and benefits of not vaccinating, including regulatory noncompliance. Animals not currently vaccinated that experience a rabies exposure are at greater risk for infection and death and also put their owners and the community at risk.
D. Vaccination of wildlife and wild animal hybrids
The safety and efficacy of parenteral rabies vaccines in wildlife and wild animal hybrids have not been established, and no rabies vaccines are currently licensed for use in these animals. Thus, any use of rabies vaccines in these animals is considered extralabel use. Zoos or research institutions may establish vaccination programs in an attempt to protect valuable animals, but these should not replace appropriate public health activities that protect humans (see Part I. B. 1. d) (3)).
E. Accidental human exposure to rabies vaccines
Human exposure to parenteral animal rabies vaccines listed in Appendix 1 does not constitute a risk for rabies virus infection. Human exposure to vaccinia-vectored oral rabies vaccines should be reported to state health officials. 111,112
F. Rabies certificates
All agencies and veterinarians should use Form 51, the rabies vaccination certificate recommended by the National Association of State Public Health Veterinarians, 53 or should use an equivalent. The form must be completed in full and signed by the administering or supervising veterinarian. Computer-generated forms containing the same information are also acceptable.
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Appendix 1
Rabies vaccines licensed and marketed in the United States, 2016.
Product name Produced by Marketed by For use in Dose Age at primary vaccination * Booster vaccination Route of inoculation Monovalent (inactivated) RABVAC 1 Boehringer Ingelheim Vetmedica Inc License No. 124 Boehringer Ingelheim Vetmedica Inc Dogs and cats 1 mL 3 mo Annually IM or SC RABVAC 3 Boehringer Ingelheim Vetmedica Inc License No. 124 Boehringer Ingelheim Vetmedica Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Horses 2 mL 3 mo Annually IM EQUI-RAB with Havlogen Merck Animal Health License No. 165A Merck Animal Health Horses 1 mL 4 mo Annually IM DEFENSOR 1 Zoetis License No. 190 Zoetis Dogs 1 mL 3 mo Annually IM or SC Cats 1 mL 3 mo Annually SC DEFENSOR 3 Zoetis License No. 190 Zoetis Dogs 1 mL 3 mo 1 year later and triennially IM or SC Cats 1 mL 3 mo 1 year later and triennially SC Sheep and cattle 2 mL 3 mo Annually IM NOBIVAC: 1-Rabies Zoetis License No. 190 Merck Animal Health Dogs 1 mL 3 mo Annually IM or SC Cats 1 mL 3 mo Annually SC NOBIVAC: 3-Rabies and 3-Rabies CA Zoetis License No. 190 Merck Animal Health Dogs 1 mL 3 mo 1 year later and triennially IM or SC Cats 1 mL 3 mo 1 year later and triennially SC Sheep and cattle 2 mL 3 mo Annually IM IMRAB 1 Merial Inc License No.298 Merial Inc Dogs and cats 1 mL 3 mo Annually SC IMRAB 1 TF Merial Inc License No.298 Merial Inc Dogs and cats 1 mL 3 mo Annually SC IMRAB 3 Merial Inc License No.298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Sheep 2 mL 3 mo 1 year later and triennially IM or SC Cattle and horses 2 mL 3 mo Annually IM or SC Ferrets 1 mL 3 mo Annually SC IMRAB 3TF Merial Inc License No.298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Ferrets 1 mL 3 mo Annually SC IMRAB Large Animal Merial Inc License No.298 Merial Inc Dogs and cats 1 mL 3 mo 1 year later and triennially IM or SC Cattle and horses 2 mL 3 mo Annually IM or SC Sheep 2 mL 3 mo 1 year later and triennially IM or SC Monovalent (rabies glycoprotein; live canary pox vector) PUREVAX Feline Rabies Merial Inc License No.298 Merial Inc Cats 1 mL 3 mo Annually SC PUREVAX Feline Merial Inc License No.298 Merial Inc Cats 1 mL 3 mo 1 year later and triennially SC Rabies 3YR Combination (inactivated) Equine POTOMAVAC + Merial Inc License No. 298 Merial Inc Horses 1 mL 3 mo Annually IM IMRAB Combination (rabies glycoprotein; live canary pox vector) PUREVAX Feline 3/Rabies Merial Inc License No.298 Merial Inc Cats 1 mL 8 wk Every 3 to 4 wk until 3 mo and annually SC 3 mo 3 to 4 wk later and annually SC PUREVAX Feline 4/Rabies Merial Inc License No.298 Merial Inc Cats 1 mL 8 wk Every 3 to 4 wk until 3 mo and annually SC 3 mo 3 to 4 wk later and annually SC Oral (rabies glycoprotein; live vaccinia vector) † RABORAL V-RG Merial Inc License No.298 Merial Inc Raccoons and coyotes NA NA As determined by local authorities Oral * One month = 28 days.
† Oral rabies vaccines are restricted for use in federal and state rabies control programs.
NA = Not applicable.
Information is provided by the vaccine manufacturers and USDA APHIS's Center for Veterinary Biologics and is subject to change.
Appendix 2
Rabies vaccine manufacturer contact information
Manufacturer Phone No. URL Boehringer Ingelheim Vetmedica Inc 800–638–2226 www.bi-vetmedica.com Merck Animal Health Inc 800–521–5767 www.merck-animal-health-usa.com Merial Inc 888–637–4251 us.merial.com Zoetis 800–366–5288 www.zoetis.com 